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Increased il-6 levels may have inhibited cyp3a4, resulting in decreased clearance and increased serum levels of indinavir.

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The precise causes of the HIV lipodystrophy syndrome are not clear and are difficult to understand because in some people with HIV there may be one or more aspects of the syndrome taking placeFor instancesome people may experience fat wastingothers fat gainand others may experience both fat gain and wastingWhat is becoming increasingly clear is that unfavourable changes in the lab readings of glucosecholesteroland triglycerides over a period of several years increase the risk of diabetes and cardiovascular diseaseSo farhoweverthe many benefits of ART are much greater than the increased risk of cardiovascular disease or other side effects.

2Bilirubin Lab tests on samples of your blood may detect higher-than-normal levels of bilirubina substance produced by the liverBilirubin levels often return to normal after a few monthsbut they should be monitoredHigh levels of bilirubin can sometimes cause the skin to darken slightlygiving the appearance of a tan or mild sunburn.

3Skinhair and nails Some indinavir users have reported thinner hair or temporary loss of hairDry skindry or cracked lipsand ingrown toenails have also been reported by indinavir usersThese symptoms are sometimes referred to as ectodermal dysplasiaFor more information about options to help manage this please see CATIE’s A Practical Guide to HIV Drug Side Effects

Take indinavir on an empty stomach1 hour before meals or 2 hours after mealswith waterskim or nonfat milkjuicecoffeeor teaHoweverif indinavir upsets your stomachit may be taken with a light mealsuch as dry toast or cornflakes with skim or nonfat milkTalk to your doctor or pharmacist about what foods may be taken with indinavir.

Selected laboratory abnormalities of severe or life-threatening intensity reported in patients treated with CRIXIVAN aloneCRIXIVAN in combination with zidovudine or zidovudine plus lamivudinezidovudine aloneor zidovudine plus lamivudine are presented in Table 11.

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