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There are no data from the effect of sevelamer on fertility in humansStudies in animals have shown that sevelamer did not impair fertility in male or female rats at exposures at a human equivalent dose 2 times the maximum clinical trial dose of 13 g/daybased on a comparison of relative body surface area.

Reduced levels of ciclosporinmycophenolate mofetil and tacrolimus have been reported in transplant patients when coadministered with sevelamer hydrochloride without any clinical consequencesi.e graft rejectionThe possibility of an interaction cannot be excluded and a close monitoring of blood concentrations of mycophenolate mofetilciclosporin and tacrolimus should be considered during the use of combination and after its withdrawal.

Renagel must not be used in people with hypophosphataemialow blood phosphate levelsor with bowel obstructiona blockage in the gut

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renagel should only be given to pregnant women if clearly needed and after a careful risk benefit analysis has been conducted for both the mother and the foetus see section 5.