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As with levodopacare should be exercised in administering SINEMET to patients with a history of myocardial infarction who have residual atrialnodalor ventricular arrhythmiasIn such patientscardiac function should be monitored with particular care during the period of initial dosage adjustmentin a facility with provisions for intensive cardiac care.
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For the reasons stated abovepatients and providers are advised to monitor for melanomas frequently and on a regular basis when using SINEMET for any indicationIdeallyperiodic skin examinations should be performed by appropriately qualified individualse.gdermatologists
Carbidopa may also reduce nausea and vomiting and permit more rapid titration of levodopa.
In reproduction studies with SINEMETno effects on fertility were found in rats receiving doses of approximately two times the maximum daily human dose of carbidopa and four times the maximum daily human dose of levodopa.
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