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Clinical factors including ageracebody weightsexconcomitant medicationsand comorbidities Genetic factorsCYP2C9 and VKORC1 genotypessee CLINICAL PHARMACOLOGY
No dosage adjustment is necessary for patients with renal failureMonitor INR more frequently in patients with compromised renal function to maintain INR within the therapeutic rangesee WARNINGS AND PRECAUTIONS and Use In Specific Populations
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be sure to mention any of the following anticoagulants blood thinners such as warfarin coumadin ; antihistamines; aspirin and other nonsteroidal anti-inflammatory drugs nsaids such as ibuprofen advil, motrin and naproxen aleve, naprosyn ; carbamazepine tegretol ; cimetidine tagamet ; ketoconazole sporanox ; lithium eskalith, lithobid, lithotabs ; linezolid zyvox ; medications for anxiety, mental illness, or seizures; medications for migraine headaches such as almotriptan axert , eletriptan relpax , frovatriptan frova , naratriptan amerge , rizatriptan maxalt , sumatriptan imitrex , and zolmitriptan zomig ; metoprolol lopressor, toprol xl ; other antidepressants such as desipramine norpramin ; sedatives; sibutramine meridia ; sleeping pills; tramadol; methylene blue; and tranquilizers.