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Viramune should only be used with at least two other antiretroviral agentssee section 5.1

Because of the risk of increased exposure to Viramunecaution should be exercised if the medicinal products are given concomitantly and patients should be monitored closely.

It is recommended that HIV-infected mothers do not breast-feed their infants to avoid risking postnatal transmission of HIV and that mothers should discontinue breast-feeding if they are receiving nevirapine.

Coadministration with herbal preparations containing StJohn’s wortHypericum perforatumdue to the risk of decreased plasma concentrations and reduced clinical effects of nevirapinesee section 4.5

The interaction between nevirapine and the antithrombotic agent warfarin is complexwith the potential for both increases and decreases in coagulation time when used concomitantly.

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