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The WHI estrogen plus progestin substudy also demonstrated an increased risk of invasive breast cancersee WARNINGS AND PRECAUTIONSand Clinical Studies
Increased plasma high-density lipoproteinHDLand HDL 2 cholesterol subfraction concentrationsreduced low-density lipoproteinLDLcholesterol concentrationsincreased triglyceride levels.
PREMARIN Vaginal Cream exposure has been reported to weaken latex condomsThe potential for PREMARIN Vaginal Cream to weaken and contribute to the failure of condomsdiaphragmsor cervical caps made of latex or rubber should be considered.
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If any of the following conditions are presenthave occurred previouslyand/or have been aggravated during pregnancy or previous hormone treatmentthe patient should be closely supervisedIt should be taken into account that these conditions may recur or be aggravated during treatment with Premarinin particular:
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