Care should be taken when combining warfarin coumadin and zetia.
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Additionallythe following side effects have been reported in general useallergic reactionswhich may require treatment right awayincluding swelling of the facelipstongueand/or throat that may cause difficulty in breathing or swallowingrashand hivesraised red rashsometimes with targetshaped lesionsjoint painmuscle achesalterations in some laboratory blood testsliver problemsstomach paininflammation of the pancreasnauseadizzinesstingling sensationdepressionheadachegallstonesinflammation of the gallbladder.
EzetimibeZetiais a newly Food and Drug Administration(FDAapproved medication that selectively inhibits the intestinal absorption of cholesterol and related phytosterolsIt is approved for primary hypercholesterolemiaheterozygous familial and nonfamilial hypercholesterolemiaas monotherapy or in combination with 3-hydroxy-3-methylglutaryl coenzyme AHMG-CoAreductase inhibitorsstatinsIt is also indicated in combination with atorvastatin or simvastatin for homozygous familial hypercholesterolemia and as an adjunct to diet for homozygous sitosterolemia1
The combination of ZETIA with a statin is contraindicated in patients with active liver disease or unexplained persistent elevations in hepatic transaminase levelsWomen who are pregnant or may become pregnantBecause statins decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterolZETIA in combination with a statin may cause fetal harm when administered to pregnant womenAdditionallythere is no apparent benefit to therapy during pregnancyand safety in pregnant women has not been establishedIf the patient becomes pregnant while taking this drugthe patient should be apprised of the potential hazard to the fetus and the lack of known clinical benefit with continued use during pregnancySee Use in Specific PopulationsNursing mothersBecause statins may pass into breast milkand because statins have the potential to cause serious adverse reactions in nursing infantswomen who require ZETIA treatment in combination with a statin should be advised not to nurse their infantssee Use in Specific PopulationsPatients with a known hypersensitivity to any component of this productHypersensitivity reactions including anaphylaxisangioedemarash and urticaria have been reported with ZETIAsee ADVERSE REACTIONS
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